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Synthesis and Conformational Analysis of Macrocycles Related to 10‐Oxa‐epothilone
Author(s) -
Quintard Delphine,
Bertrand Philippe,
Bachmann Christian,
Gesson JeanPierre
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200400212
Subject(s) - chemistry , ring closing metathesis , epothilone , stereochemistry , aldehyde , metathesis , salt metathesis reaction , ring (chemistry) , organic chemistry , catalysis , polymerization , polymer
A short and convergent synthesis of macrocyclic lactones related to 10‐oxa‐epothilone is based on aldolisation of a 3‐(2′‐methylallyloxy) aldehyde derived from methyl (2 S )‐3‐hydroxy‐2‐methylpropionate followed by ring‐closing metathesis. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)