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Enantiocontrolled Synthesis of 3‐Pyrrolines from α‐Amino Allenes
Author(s) -
Horváth Attila,
Benner Jessica,
Bäckvall JanE.
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200400211
Subject(s) - chemistry , enantiomer , derivative (finance) , optically active , enantioselective synthesis , organic chemistry , stereochemistry , combinatorial chemistry , catalysis , financial economics , economics
Cyclization of α‐amino allenes in the presence of N‐ bromosuccinimide afforded pyrrolines in good yields. The products were obtained with high enantiomeric excesses when optically active allenes were used as substrates. The synthesis of a 2,5‐dehydroprolinol derivative is also presented. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)