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Chemical Synthesis of GPIs and GPI‐Anchored Glycopeptides
Author(s) -
Guo Zhongwu,
Bishop Lee
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200400198
Subject(s) - glycopeptide , chemistry , stereochemistry , biochemistry , combinatorial chemistry , antibiotics
This microreview summarizes some recent progress in the study of glycosylphosphatidylinositols (GPI), focusing on the strategies established for the synthesis of optically pure myo ‐inositol derivatives and complex GPIs and GPI conjugates. Although in the past decade many GPIs have been achieved by linear, convergent and solid‐phase synthesis, the GPIs with 2‐ O ‐acylated inositol residues and the GPI conjugates of peptides and glycopeptides have not been accomplished until recently. The successful coupling of peptides and glycopeptides to GPIs brings new promises to this area, but the scope of the relevant designs, in particular their application to more complex structures such as GPI‐anchored glycoproteins, remains untested. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)