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A Fast Access to Non‐Symmetrically Substituted 1,3‐Alternate Conformers of Calix[4]arenes
Author(s) -
Kleij Arjan W.,
Prados Pilar,
de Mendoza Javier
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200400161
Subject(s) - chemistry , conformational isomerism , calixarene , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , molecule
A simple and direct protocol is reported for the synthesis of the first non‐symmetrically substituted 1,3‐alternate conformers of calix[4]arenes by selective mono‐deacylation of a tribenzoyl precursor under basic conditions, followed by dialkylation. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)