New Chiral 1,2‐Diamines and Their Use in Zinc‐Catalyzed Asymmetric Hydrosilylation of Acetophenone | Zendy

Bette Virginie | Zendy; Mortreux André | Zendy; Ferioli Federico | Zendy; Martelli Gianluca | Zendy; Savoia Diego | Zendy; Carpentier JeanFrançois | Zendy

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New Chiral 1,2‐Diamines and Their Use in Zinc‐Catalyzed Asymmetric Hydrosilylation of Acetophenone

Author(s) -

Bette Virginie,

Mortreux André,

Ferioli Federico,

Martelli Gianluca,

Savoia Diego,

Carpentier JeanFrançois

Publication year - 2004

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200400129

Subject(s) - hydrosilylation , diamine , acetophenone , chemistry , ethylene diamine , catalysis , ligand (biochemistry) , enantioselective synthesis , polymer chemistry , chiral ligand , organic chemistry , asymmetric induction , medicinal chemistry , nuclear chemistry , receptor , biochemistry

The preparation of two new series of chiral 1,2‐diamines and their use in the [ZnR 2 ‐diamine]‐catalyzed asymmetric hydrosilylation of acetophenone with poly(methylhydrosiloxane) (PMHS) in an aprotic medium is reported. The effect of structural modifications of the secondary diamine ligand, in particular a possible cooperative effect of two different types of chiral centers, on the N ‐benzylic side‐arms and on the ethylene bridge of the diamine skeleton, has been investigated. A new diamine ligand giving up to 91% ee is described. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

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