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Dialkylation of Various Butane‐2,3‐diacetals Using Allylsilane and 1,8‐Bis(trimethylsilyl)‐2,6‐octadiene
Author(s) -
Mariet Natacha,
Pellissier Hélène,
IbrahimOuali Malika,
Santelli Maurice
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200400042
Subject(s) - chemistry , trimethylsilyl , butane , organic chemistry , medicinal chemistry , stereochemistry , catalysis
We report in this paper a greatly improved procedure for the formation of a range of 1‐acetyl‐1‐methyl‐2,5‐divinylcyclopentanes from 1,8‐bis(trimethylsilyl)octa‐2,6‐diene (BISTRO) and 1,2‐diacetals prepared directly from biacetyl. These 1‐acetyl‐1‐methyl‐2,5‐divinylcyclopentanes are building blocks for the synthesis of 2‐ and 3‐methoxy‐12‐oxo‐17β‐vinylestranes. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)