Premium
Glycosylation of Cyclitols: Synthesis of Neamine‐Type Aminoglycosides
Author(s) -
Verhelst Steven H. L.,
Magnée Lisette,
Wennekes Tom,
Wiedenhof Wouter,
van der Marel Gijsbert A.,
Overkleeft Herman S.,
van Boeckel Constant A. A.,
van Boom Jacques H.
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200400020
Subject(s) - cyclitol , chemistry , glycosylation , aminoglycoside , stereochemistry , aminocyclitol , combinatorial chemistry , biochemistry , antibiotics , receptor , inositol
In this paper, a glycosylation‐based approach towards novel aminoglycoside analogues is presented. Three different cyclitol building blocks were condensed with different thioglycosides to give, after removal of the protective groups, several neamine‐type analogs varying in the positioning and the stereochemistry of the amino functions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)