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Cover Picture: Synthesis and Biological Evaluation of Imino Sugar−Oligoarabinofuranoside Hybrids, a New Class of Mycobacterial Arabinofuranosyltransferase Inhibitors (Eur. J. Org. Chem. 14/2003)
Author(s) -
Marotte Karine,
Ayad Tahar,
Génisson Yves,
Besra Gurdyal S.,
Baltas Michel,
Prandi Jacques
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200390230
Subject(s) - chemistry , stereochemistry , cover (algebra) , combinatorial chemistry , in vitro , courtesy , biochemistry , mechanical engineering , engineering , political science , law
Abstract The cover picture shows a schematic view of the expected cooperative effect of linking a potential mycobacterial arabinosyltransferase inhibitor to an acceptor‐like ligand. Important enhancement of the in vitro inhibitory porperties of various hydroxylated and fluorinated pyrrolidines was obseved when they were covalently linked to a single arabinofuranosidic unit while a longer triarabinofuranoside was deleterious for the inhibition. Details are discussed in the article by M. Baltas and J. Prandi et al. on p. 2557 ff. Photo courtesy of P. Gournon, Institut Pasteur, Paris.