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Conicaquinones A and B, Two Novel Cytotoxic Terpene Quinones from the Mediterranean Ascidian Aplidium conicum
Author(s) -
Aiello Anna,
Fattorusso Ernesto,
Luciano Paolo,
Menna Marialuisa,
Esposito Giuseppe,
Iuvone Teresa,
Pala David
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200390136
Subject(s) - chemistry , stereochemistry , cytotoxic t cell , terpene , cytotoxicity , in vitro , biochemistry
Two new unique cytotoxic metabolites, conicaquinones A ( 1 ) and B ( 2 ), each possessing a 1,1‐dioxo‐1,4‐thiazine ring, were isolated from the Mediterranean ascidian Aplidium conicum . Their structures were established by an extensive spectroscopic analysis. Compounds 1 and 2 exhibited a strong cytotoxicity in vitro against rat glioma cells. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)