Premium
Investigations into the Regioselective C ‐Deuteration of Acyclic and Exocyclic Enolates
Author(s) -
Eames Jason,
Coumbarides Gregory S.,
Suggate Michael J.,
Weerasooriya Neluka
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200390103
Subject(s) - regioselectivity , chemistry , deuterium , stereochemistry , aryl , ketone , medicinal chemistry , organic chemistry , alkyl , catalysis , physics , quantum mechanics
Results are reported on the regioselective C ‐deuteration of a series of related acyclic and exocyclic enolates derived from substituted aryl ketones. We comment on factors, such as the presence of additives and the structural nature of the enolate, that influence the observed C ‐deuteration and discuss the role of the deuterium donor. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)