Organometallic Control over the Regiospecificity of Functionalization Reactions: 1,2,3‐Trifluorobenzene and Bromo Derivatives thereof as Substrates | Zendy

Heiss Christophe | Zendy; Schlosser Manfred | Zendy

Premium

Organometallic Control over the Regiospecificity of Functionalization Reactions: 1,2,3‐Trifluorobenzene and Bromo Derivatives thereof as Substrates

Author(s) -

Heiss Christophe,

Schlosser Manfred

Publication year - 2003

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200390078

Subject(s) - chemistry , halogen , deprotonation , bromine , surface modification , organic chemistry , halogenation , group 2 organometallic chemistry , combinatorial chemistry , molecule , ion , alkyl

In a case study, 1,2,3‐trifluorobenzene was functionalized at each of the two vacant positions (producing the benzoic acids 1 and 2 ) and, in addition, bromine was introduced into all available positions (producing the benzoic acids 3 − 5 ). The required regioflexibility was achieved by applying novel organometallic recipes such as deprotonation‐triggered halogen migrations and site‐discriminating competitive halogen−metal permutations. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research