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Plakohypaphorines A−C, Iodine‐Containing Alkaloids from the Caribbean Sponge Plakortis simplex
Author(s) -
Campagnuolo Claudio,
Fattorusso Ernesto,
TaglialatelaScafati Orazio
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200390030
Subject(s) - sponge , chemistry , stereochemistry , iodine , isolation (microbiology) , organic chemistry , botany , microbiology and biotechnology , biology
Investigation of the most polar fractions obtained from the organic extract of the Caribbean marine sponge Plakortis simplex has led to the isolation of three novel iodine‐containing tryptophan betaines structurally related to the known hypaphorine ( 5 ), which have been named plakohypaphorine A ( 2 ), B ( 3 ) and C ( 4 ). Their structures have been determined by spectroscopic methods. Isolation of compounds 2−4 is particularly remarkable since it represents the first finding of iodoindole derivatives in a natural source, either marine or terrestrial. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)