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The Unexpected Conversion of 1,5,8,12‐Tetraazadodecane‐Glyoxal Bisaminal into Its Amidinium Salt in an Acidic Medium
Author(s) -
Bernard Hélène,
Del Rio Garcia Eugenia,
Ferec Sonia,
Kervarec Nelly,
Handel Henri
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200390026
Subject(s) - chemistry , glyoxal , salt (chemistry) , hydrochloric acid , aqueous medium , lactam , aqueous solution , organic chemistry , combinatorial chemistry
When refluxed in aqueous hydrochloric acid solution, 1,5,8,12‐tetraazadodecane‐glyoxal bisaminal is quantitatively converted into its amidinium salt, which is a lactam precursor. The mechanism of this unexpected reaction is discussed. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)