Synthesis of 3′−3′‐Linked Pyrimidine Oligonucleotides Containing an Acridine Moiety for Alternate Strand Triple Helix Formation | Zendy

Amato Jussara | Zendy; Galeone Aldo | Zendy; Oliviero Giorgia | Zendy; Mayol Luciano | Zendy; Piccialli Gennaro | Zendy; Varra Michela | Zendy

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Synthesis of 3′−3′‐Linked Pyrimidine Oligonucleotides Containing an Acridine Moiety for Alternate Strand Triple Helix Formation

Author(s) -

Amato Jussara,

Galeone Aldo,

Oliviero Giorgia,

Mayol Luciano,

Piccialli Gennaro,

Varra Michela

Publication year - 2004

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200300803

Subject(s) - triple helix , phosphodiester bond , chemistry , acridine , moiety , oligonucleotide , stereochemistry , pyrimidine , nucleotide , dna , biochemistry , organic chemistry , rna , gene

Oligonucleotides with a 3′−3′ inversion of polarity, containing an acridine moiety attached to the nucleotide base flanking the 3′−3′ phosphodiester bond, have been synthesised, characterised and used to form alternate‐strand triple helix complexes. These have been investigated by UV melting studies and CD experiments. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

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