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Synthesis of 3′−3′‐Linked Pyrimidine Oligonucleotides Containing an Acridine Moiety for Alternate Strand Triple Helix Formation
Author(s) -
Amato Jussara,
Galeone Aldo,
Oliviero Giorgia,
Mayol Luciano,
Piccialli Gennaro,
Varra Michela
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300803
Subject(s) - triple helix , phosphodiester bond , chemistry , acridine , moiety , oligonucleotide , stereochemistry , pyrimidine , nucleotide , dna , biochemistry , organic chemistry , rna , gene
Abstract Oligonucleotides with a 3′−3′ inversion of polarity, containing an acridine moiety attached to the nucleotide base flanking the 3′−3′ phosphodiester bond, have been synthesised, characterised and used to form alternate‐strand triple helix complexes. These have been investigated by UV melting studies and CD experiments. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)