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Asymmetric Synthesis of β‐Amino Acid and Amide Derivatives by Catalytic Conjugate Addition of Aromatic Amines to N ‐Alkenoylcarbamates
Author(s) -
Li Kelin,
Cheng Xiaohui,
Hii King Kuok Mimi
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300740
Subject(s) - chemistry , conjugate , enantioselective synthesis , catalysis , amide , primary (astronomy) , palladium , organic chemistry , amino acid , medicinal chemistry , mathematical analysis , physics , mathematics , astronomy , biochemistry
We report a highly active palladium catalyst for the enantioselective conjugate addition of primary aromatic amines to N ‐alkenoylcarbamates, furnishing β‐amino N ‐Boc‐amides in extremely high yields (>99 %) and unprecedented optical purity (>99 % ee ) with just 2 mol % catalyst loading. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)