Asymmetric Synthesis of β‐Amino Acid and Amide Derivatives by Catalytic Conjugate Addition of Aromatic Amines to  N ‐Alkenoylcarbamates | Zendy

Li Kelin | Zendy; Cheng Xiaohui | Zendy; Hii King Kuok Mimi | Zendy

Premium

Asymmetric Synthesis of β‐Amino Acid and Amide Derivatives by Catalytic Conjugate Addition of Aromatic Amines to N ‐Alkenoylcarbamates

Author(s) -

Li Kelin,

Cheng Xiaohui,

Hii King Kuok Mimi

Publication year - 2004

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200300740

Subject(s) - chemistry , conjugate , enantioselective synthesis , catalysis , amide , primary (astronomy) , palladium , organic chemistry , amino acid , medicinal chemistry , mathematical analysis , physics , mathematics , astronomy , biochemistry

We report a highly active palladium catalyst for the enantioselective conjugate addition of primary aromatic amines to N ‐alkenoylcarbamates, furnishing β‐amino N ‐Boc‐amides in extremely high yields (>99 %) and unprecedented optical purity (>99 % ee ) with just 2 mol % catalyst loading. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research