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Efficient Fe III ‐Catalyzed Synthesis of Bis(indolyl)methanes in Ionic Liquids
Author(s) -
Ji ShunJun,
Zhou MinFeng,
Gu DaGong,
Jiang ZhaoQin,
Loh TeckPeng
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300719
Subject(s) - chemistry , ionic liquid , catalysis , electrophilic substitution , electrophile , ionic bonding , organic chemistry , medicinal chemistry , ion
An efficient synthesis of bis(indolyl)methanes through Fe III ‐catalyzed electrophilic substitution reactions of indoles with various aldehydes in ionic liquid is described. It was found that the ionic liquids involving FeCl 3 ·6H 2 O were the most efficient catalytic systems, and could be simply recycled without significant loss of activity. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)