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Asymmetric Electrophilic α‐Amination of Carbonyl Groups
Author(s) -
Greck Christine,
Drouillat Bruno,
Thomassigny Christine
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300657
Subject(s) - electrophilic amination , chemistry , electrophile , amination , reagent , organic chemistry , enantioselective synthesis , carbonyl group , catalysis , combinatorial chemistry , organocatalysis , medicinal chemistry
The electrophilic amination constitutes an unconventional C−N bond‐forming reaction. Asymmetric versions have been developed using chiral reagents or catalysts and starting from optically pure substrates. The aminated products can be obtained with high stereoselectivities. These methodologies are flexible routes for the synthesis of α‐amino acids and nitrogen heterocycles. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)