Premium
Suzuki Cross‐Coupling Reactions between Alkenylboronic Acids and Aryl Bromides Catalysed by a Tetraphosphane‐Palladium Catalyst
Author(s) -
Peyroux Eugénie,
Berthiol Florian,
Doucet Henri,
Santelli Maurice
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300627
Subject(s) - chemistry , cyclopentane , catalysis , aryl , palladium , nitrile , styrene , coupling reaction , steric effects , nitro , organic chemistry , medicinal chemistry , suzuki reaction , alkyl , copolymer , polymer
A range of alkenylboronic acids undergo Suzuki cross‐coupling with aryl bromides in good yields in the presence of [PdCl(C 3 H 5 )] 2 / cis , cis , cis ‐1,2,3,4‐tetrakis[(diphenylphosphanyl)methyl]cyclopentane as a catalyst. A wide variety of 1‐arylprop‐1‐enes, 2‐arylprop‐1‐enes, 2‐arylbut‐1‐enes and 1,1‐diarylethylene or styrene derivatives have been prepared. Moreover, the reaction tolerates several functions, such as acetyl, formyl, nitrile or nitro. Furthermore, this catalyst can be used at low loading, even for reactions of sterically hindered substrates. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)