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Synthesis, Characterization, and Reaction of Crystalline Fischer’s Glucopyranosyl Isocyanate
Author(s) -
Ichikawa Yoshiyasu,
Matsukawa Yohei,
Nishiyama Taihei,
Isobe Minoru
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300617
Subject(s) - chemistry , isocyanate , anomer , organic chemistry , characterization (materials science) , stereochemistry , polymer chemistry , nanotechnology , polyurethane , materials science
We have established a simple method for the preparation of crystalline Fischer’s glucopyranosyl isocyanate 1 . NMR spectroscopic analysis of 1 allowed the unambiguous determination of the stereochemistry at the anomeric position. Synthetic applications of glucopyranosyl isocyanate 1 were examined by its reactions with amines and alcohols to furnish a wide variety of neoglycoconjugates. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)