Transition‐Metal‐Free Sonogashira‐Type Coupling Reactions in Water | Zendy

Appukkuttan Prasad | Zendy; Dehaen Wim | Zendy; Van der Eycken Erik | Zendy

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Transition‐Metal‐Free Sonogashira‐Type Coupling Reactions in Water

Author(s) -

Appukkuttan Prasad,

Dehaen Wim,

Van der Eycken Erik

Publication year - 2003

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200300587

Subject(s) - sonogashira coupling , chemistry , halide , transition metal , aryl , coupling reaction , copper , palladium , combinatorial chemistry , metal , organic chemistry , catalysis , alkyl

Microwave‐assisted transition‐metal‐free Sonogashira‐type coupling reactions are described. The reactions are run in water as the sole solvent, without the need for copper( I ) or any transition‐metal−phosphane complex. The scope of the methodology was tested by reaction of a wide variety of aryl halides and heteroaryl halides. The reaction was also investigated under conventional heating conditions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

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