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Green Protocol for the Biginelli Three‐Component Reaction: Ag 3 PW 12 O 40 as a Novel, Water‐Tolerant Heteropolyacid for the Synthesis of 3,4‐Dihydropyrimidinones
Author(s) -
Yadav Jhillu S.,
Reddy Basi V. Subba,
Sridhar Pamu,
Reddy Joolakanti S. S.,
Nagaiah Kommu,
Lingaiah Nakka,
Saiprasad Potharaja S.
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300559
Subject(s) - chemistry , biginelli reaction , aldehyde , reusability , catalysis , urea , salt (chemistry) , heterogeneous catalysis , organic chemistry , solvent , condensation , green chemistry , component (thermodynamics) , ionic liquid , physics , software , computer science , thermodynamics , programming language
Abstract Biginelli three‐component condensation of an aldehyde, β‐keto ester, and urea proceeds smoothly on the surface of the silver salt of heteropolyacid (HPA), i.e. Ag 3 PW 12 O 40 , in water to afford the corresponding 3,4‐dihydropyrimidinones in high‐to‐quantitative yields under mild conditions. The heterogeneous solid acid provides ease of separation of the catalyst and isolation of the products. The recovered catalyst can be recycled in subsequent reactions with consistent activity. Compared to the classical Biginelli reaction conditions, this new method has the advantages of improved yields, reusability of the catalyst, an eco‐friendly solvent, ease of isolation of products, and simplicity in the experimental procedure. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)