Premium
Ring‐Expansion of MCPs in the Presence of DIAD or DEAD and Lewis Acids
Author(s) -
Shao LiXiong,
Shi Min
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300515
Subject(s) - diad , chemistry , lewis acids and bases , cyclobutanone , ring (chemistry) , oxygen atom , stereochemistry , medicinal chemistry , organic chemistry , molecule , catalysis , copolymer , polymer
Treatment of methylenecyclopropanes (MCPs) with DIAD or DEAD in MeCN under mild conditions in the presence of Lewis acid Zr(OTf) 4 gave the cyclobutanone ring‐expansion products in good to high yields based on the employed DIAD or DEAD. From a deuterium labeling experiment, the oxygen atom is derived from ambient water. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom