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Preparation of [1,2,3,4,5‐ 13 C 5 ]‐5‐Amino‐4‐oxopentanoic Acid (ALA) − Design of a Synthetic Scheme to Prepare Any 13 C‐ and 15 N‐Isotopomer with High Isotopic Enrichment
Author(s) -
ShresthaDawadi Prativa Bade,
Lugtenburg Johan
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300408
Subject(s) - levulinic acid , chemistry , isotopomers , amino acid , yield (engineering) , bacteriochlorophyll , heme , combinatorial chemistry , photosynthesis , stereochemistry , catalysis , organic chemistry , biochemistry , molecule , materials science , metallurgy , enzyme
5‐Amino‐4‐oxopentanoic acid (5‐aminolevulinic acid) is a precursor in the biosynthesis of the biologically active porphyrins such as chlorophyll, bacteriochlorophyll, heme, etc. These systems are central in photosynthesis, oxygen transport, electron transport, etc. In this paper we describe a simple scheme to prepare any isotopomer of 5‐aminolevulinic acid in a few steps in high yield. Using a similar scheme, levulinic acid can now also be prepared in any isotopomeric form. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)