Synthesis of Racemic and Enantiomerically Pure ( R*,R*,R* )‐Tris(α‐methylbenzyl)phosphane − X‐ray Crystal Structures of the Phosphane Oxides and Borane Complexes | Zendy

Wyatt Paul | Zendy; Eley Helen | Zendy; Charmant Jonathan | Zendy; Daniel Berian J. | Zendy; Kantacha Anob | Zendy

Premium

Synthesis of Racemic and Enantiomerically Pure ( R*,R*,R* )‐Tris(α‐methylbenzyl)phosphane − X‐ray Crystal Structures of the Phosphane Oxides and Borane Complexes

Author(s) -

Wyatt Paul,

Eley Helen,

Charmant Jonathan,

Daniel Berian J.,

Kantacha Anob

Publication year - 2003

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200300396

Subject(s) - chemistry , electrophile , iodide , borane , nucleophile , enantioselective synthesis , reagent , tris , stereochemistry , medicinal chemistry , organic chemistry , catalysis , biochemistry

An asymmetric synthesis of C 3 ‐symmetric phosphane 1 has been achieved. Two of the α‐methylbenzyl groups were introduced as nucleophiles (using an α‐methylbenzyl Grignard reagent), and asymmetry was introduced by resolution using ( R )‐α‐methylbenzylamine. The final α‐methylbenzyl group was introduced as an electrophile (α‐methylbenzyl iodide) in a modestly selective reaction. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research