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An Efficient Method for the Large‐Scale Preparation of 3‐ O ‐Acetyl‐11‐oxo‐β‐boswellic Acid and Other Boswellic Acids
Author(s) -
Jauch Johann,
Bergmann Jochen
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300386
Subject(s) - chemistry , incense , arachidonate 5 lipoxygenase , stereochemistry , organic chemistry , enzyme , philosophy , theology , arachidonic acid
3‐ O ‐Acetyl‐11‐oxo‐β‐boswellic acid (AKBA), found in incense, is a potent inhibitor of 5‐lipoxygenase, p38 and p42 MAP kinase and topoisomerases. Starting from crude extracts from incense, procedures are presented for the efficient large‐scale synthesis of AKBA and other boswellic acids (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)