Cyrmenins, Novel Antifungal Peptides Containing a Nitrogen‐Linked β‐Methoxyacrylate Pharmacophore: Isolation and Structural Elucidation | Zendy

Leibold Thomas | Zendy; Sasse Florenz | Zendy; Reichenbach Hans | Zendy; Höfle Gerhard | Zendy

Premium

Cyrmenins, Novel Antifungal Peptides Containing a Nitrogen‐Linked β‐Methoxyacrylate Pharmacophore: Isolation and Structural Elucidation

Author(s) -

Leibold Thomas,

Sasse Florenz,

Reichenbach Hans,

Höfle Gerhard

Publication year - 2004

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200300367

Subject(s) - chemistry , pharmacophore , myxobacteria , antifungal , stereochemistry , residue (chemistry) , biochemistry , bacteria , microbiology and biotechnology , genetics , biology

The novel antifungal metabolites cyrmenin A, B 1 , and B 2 ( 1 − 3 ) were isolated from Archangium gephyra and Cystobacter armeniaca strains (myxobacteria). The cyrmenins are modified N ‐acyldipeptide esters containing a didehydroalanine, a 3‐ O ‐methyl‐didehydroserine and a (2 E ,4 Z )‐undecadienoic or ‐dodecadienoic acid residue. These compounds represent the first bacterial counterparts of strobilurins that are characterized by an α‐substituted β‐methoxyacrylate pharmacophore. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research