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Pd‐Catalyzed Coupling Reactions Involving Propargylic/Allenylic Species
Author(s) -
Ma Shengming
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300352
Subject(s) - chemistry , regioselectivity , steric effects , catalysis , ligand (biochemistry) , coupling reaction , coupling (piping) , electronic effect , combinatorial chemistry , medicinal chemistry , computational chemistry , stereochemistry , organic chemistry , mechanical engineering , engineering , biochemistry , receptor
Abstract In this review, the Pd‐catalyzed coupling reaction involving propargylic/allenylic species is discussed. In these reactions, η 1 ‐ and η 3 ‐propargylic/allenylic species have been proposed as the key intermediates for the selective formation of either allenes or alkynes. It should be noted that, in most cases, allenes are formed as the major products. Electronic, steric, and ligand effects have been observed for the control of the regioselectivity. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)