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Synthesis and Chemical Reactivity of α‐Oxo Aldehyde‐Supported Silicas
Author(s) -
Kar Samiran,
Joly Pascal,
Granier Michel,
Melnyk Oleg,
Durand JeanOlivier
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300347
Subject(s) - aldehyde , chemistry , hydroxylamine , reactivity (psychology) , hydrazine (antidepressant) , derivative (finance) , organic chemistry , chemical modification , combinatorial chemistry , polymer chemistry , catalysis , chromatography , medicine , alternative medicine , pathology , financial economics , economics
The synthesis and characterisation of α‐oxo aldehyde‐supported silicas by the sol‐gel procedure is described. The glyoxylyl group was generated after gelation, either by periodic oxidation of gluconamide chains or by deprotection of a diisopropylthioacetal‐protected derivative. The accessibility and reactivity of the supported α‐oxo aldehyde function was investigated in model reactions with hydroxylamine and hydrazine derivatives. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)