Novel DNA‐Damaging Tropolone Derivatives from  Goupia glabra | Zendy

MesaSiverio Dulce | Zendy; EstévezBraun Ana | Zendy; Ravelo Ángel G. | Zendy; Murguia Jose R. | Zendy; RodríguezAfonso Abigail | Zendy

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Novel DNA‐Damaging Tropolone Derivatives from Goupia glabra

Author(s) -

MesaSiverio Dulce,

EstévezBraun Ana,

Ravelo Ángel G.,

Murguia Jose R.,

RodríguezAfonso Abigail

Publication year - 2003

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200300284

Subject(s) - tropolone , chemistry , adduct , stereochemistry , derivative (finance) , dna , dna damage , mutant , yeast , naphthalene , organic chemistry , biochemistry , financial economics , economics , gene

Two novel tropolone derivatives 1 and 2 have been isolated from Goupia glabra . Their structures were determined by extensive 1D and 2D NMR spectroscopic studies. Compound 2 constitutes the first example isolated from a natural source of a Diels−Alder adduct between a tropolone and a naphthalene derivative. Compounds 1 and 2 exhibit significant toxicity towards a panel of DNA damage checkpoint defective yeast mutants, and behave as genotoxins, which highlights their potential to be used as anticancer drugs. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

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