Premium
Novel DNA‐Damaging Tropolone Derivatives from Goupia glabra
Author(s) -
MesaSiverio Dulce,
EstévezBraun Ana,
Ravelo Ángel G.,
Murguia Jose R.,
RodríguezAfonso Abigail
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300284
Subject(s) - tropolone , chemistry , adduct , stereochemistry , derivative (finance) , dna , dna damage , mutant , yeast , naphthalene , organic chemistry , biochemistry , financial economics , economics , gene
Two novel tropolone derivatives 1 and 2 have been isolated from Goupia glabra . Their structures were determined by extensive 1D and 2D NMR spectroscopic studies. Compound 2 constitutes the first example isolated from a natural source of a Diels−Alder adduct between a tropolone and a naphthalene derivative. Compounds 1 and 2 exhibit significant toxicity towards a panel of DNA damage checkpoint defective yeast mutants, and behave as genotoxins, which highlights their potential to be used as anticancer drugs. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)