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Organic Chemistry of Vitamin D Analogues (Deltanoids)
Author(s) -
Posner Gary H.,
Kahraman Mehmet
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300264
Subject(s) - chemistry , catabolism , steroid , vitamin d and neurology , combinatorial chemistry , biochemistry , stereochemistry , metabolism , medicine , hormone
An increasing number of synthetic vitamin D analogues (deltanoids) are now being used as sensitive molecular biology probes and also as new drug candidates and new drugs for treatment of various human diseases. The design and stereocontrolled synthesis of such new deltanoids are guided by considering catabolism inhibition and by using large steroidal chirons and small steroid‐derived chirons. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)