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Synthesis of Benzo[ a ]pyren‐6‐yl‐Substituted Carboxylic Acids
Author(s) -
Dyker Gerald,
Kadzimirsz Daniel
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300217
Subject(s) - chemistry , carboxylic acid , halogenation , pyrene , organic chemistry , heck reaction , palladium , catalysis
The title compounds were synthesized from benzo[ a ]pyrene in three to four steps, depending on the chain length of the carboxylic acid. After iodination, alkanone chains were introduced by special Heck reactions. Transformation into carboxylic acids was achieved by haloform reaction and by Willgerodt−Kindler reaction. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)