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Synthesis of Differently Disubstituted 2,2′‐Bipyridines by a Modified Negishi Cross‐Coupling Reaction
Author(s) -
Lützen Arne,
Hapke Marko,
Staats Holger,
Bunzen Jens
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300192
Subject(s) - negishi coupling , chemistry , coupling reaction , coupling (piping) , computational chemistry , combinatorial chemistry , organic chemistry , catalysis , mechanical engineering , engineering
A general practical approach to a number of differently disubstituted 2,2′‐bipyridines from substituted 2‐bromo‐ and 2‐chloropyridines by application of modified Negishi cross‐coupling conditions has been developed. These 2,2′‐bipyridines carry versatile functional groups that can be elaborated further, as demonstrated for some examples. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)