Premium
A New Versatile Synthesis of Macrotricyclic Tetraazacycloalkane‐Based Ligands from Bis‐aminal Derivatives
Author(s) -
Develay Stéphanie,
Tripier Raphaël,
Chuburu Françoise,
Le Baccon Michel,
Handel Henri
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300188
Subject(s) - cyclen , chemistry , aminal , cyclam , glyoxal , condensation , combinatorial chemistry , synthon , stereochemistry , organic chemistry , metal , physics , thermodynamics
A new powerful synthesis of symmetrical (two‐step) or dissymmetrical (three‐step) macrotricyclic cyclen‐ or cyclam‐based ligands is reported. In this procedure, the starting materials are bis‐aminals derived from condensation of cyclen or cyclam with glyoxal. The two macrocyclic subunits are linked by two aromatic spacers through nitrogen atoms. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)