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Synthesis and Electrochemical Studies of New Antimalarial Endoperoxides
Author(s) -
Najjar Fadia,
Baltas Michel,
Gorrichon Liliane,
Moreno Yolande,
Tzedakis Theodore,
Vial Henri,
AndréBarrès Christiane
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300165
Subject(s) - chemistry , electrochemistry , diastereomer , plasmodium falciparum , artemisinin , cathodic protection , carbon 13 nmr , combinatorial chemistry , organic chemistry , stereochemistry , malaria , electrode , immunology , biology
Structural analogues of endoperoxides belonging to the family of G factors have been synthesized under Mannich‐type conditions. The structures of the different diastereoisomers have been established from NMR spectroscopic data. Their cathodic peak potentials have been determined by thin layer electrochemistry under potentiostatic conditions, and compared to artemisinin. These endoperoxides were evaluated in vitro against Plasmodium falciparum and showed moderate to good activity. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)