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First Synthesis of (8‐ 2 H 3 )‐(all‐ rac )‐δ‐Tocopherol
Author(s) -
Mazzini Francesco,
Alpi Emanuele,
Salvadori Piero,
Netscher Thomas
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300138
Subject(s) - chemistry , tocopherol , mass spectrometry , organic chemistry , chromatography , vitamin e , antioxidant
Trideuterated tocopherols were needed to be used as internal standards for our study about simultaneous quantitative determination of tocopherols in foodstuffs by mass spectrometry. Whilst procedures for trideuterated α‐tocopherol have been recently optimized, no method is reported as regards δ‐tocopherol. Different synthetic approaches are discussed, as well as the first procedure for the synthesis of (8‐ 2 H 3 )‐(all‐ rac )‐δ‐tocopherol. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)