Premium
Synthesis and Evaluation of a Broad Range of New Chiral (Aminoalkyl)phosphane Ligands for Asymmetric Hydrogen‐Transfer Reduction of Prochiral Ketones
Author(s) -
Léautey Matthieu,
Jubault Philippe,
Pannecoucke Xavier,
Quirion JeanCharles
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300131
Subject(s) - chemistry , enantioselective synthesis , transfer hydrogenation , hydrogen , combinatorial chemistry , organic chemistry , reduction (mathematics) , stereochemistry , catalysis , geometry , mathematics , ruthenium
Twenty new chiral (aminoalkyl)phosphane ligands have been prepared from four enantiomerically pure advanced chiral compounds. We describe their use for asymmetric hydrogen‐transfer reduction of three prochiral ketones. Enantioselectivities up to 90% were obtained. We investigated the influence on the enantioselectivity of each part of these new (aminoalkyl)phosphane ligands. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)