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The Aldol‐Grob Reaction: Regioselective Synthesis of ( E )‐Alkenes from Aldehydes and Ketones with Ytterbium Triflate Catalysis
Author(s) -
Curini Massimo,
Epifano Francesco,
Maltese Federica,
Marcotullio Maria Carla
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300076
Subject(s) - chemistry , aldol reaction , trifluoromethanesulfonate , regioselectivity , catalysis , organic chemistry , hydrate , ketone , ytterbium , aldol condensation , aldehyde , solvent , medicinal chemistry , physics , optoelectronics , doping
A simple, good yielding and solvent‐free aldol‐Grob reaction sequence, catalysed by Yb(OTf) 3 hydrate, affording ( E )‐alkenes regioselectively from aldehydes and ketones is described. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)