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Construction of Spiro[pyrrolidine‐3,3′‐oxindoles] − Recent Applications to the Synthesis of Oxindole Alkaloids
Author(s) -
Marti Christiane,
Carreira Erick M.
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300050
Subject(s) - pyrrolidine , oxindole , chemistry , ring (chemistry) , context (archaeology) , chemical synthesis , stereochemistry , total synthesis , combinatorial chemistry , organic chemistry , biochemistry , in vitro , catalysis , paleontology , biology
The spiro[pyrrolidine‐3,3′‐oxindole] ring system is found at the core of a number of alkaloids, which possess significant biological activity and are interesting, challenging targets for chemical synthesis. In the present review, we report on the different strategies for the synthesis of the spiro[pyrrolidine‐3,3′‐oxindole] ring system in the context of recent synthesis of coerulescine, horsfiline, elacomine, salacin, pteropodine, alstonisine, spirotryprostatin A and B, and strychnofoline. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)