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Studies of the Biogenesis of Verrucosins, Toxic Diterpenoid Glycerides of the Mediterranean Mollusc Doris verrucosa
Author(s) -
Fontana Angelo,
Tramice Annabella,
Cutignano Adele,
d’Ippolito Giuliana,
Renzulli Licia,
Cimino Guido
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300047
Subject(s) - terpenoid , biogenesis , chemistry , glyceride , doris (gastropod) , stereochemistry , biochemistry , organic chemistry , art history , art , fatty acid , gene
The biogenesis of verrucosins, diterpenoid glycerides of the marine mollusc Doris verrucosa , has been investigated by feeding experiments with labelled precursors. Incorporation of radioactive D ‐[U‐ 14 C]‐glucose into the diterpenes proved the de novo origin of verrucosins in the mollusc. Biogenesis of glycerol and terpenoid substructures has been investigated by feeding experiment with 13 C‐labelled precursors. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)