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Efficient Large‐Scale Synthesis of Picolinic Acid‐Derived Nickel( II ) Complexes of Glycine
Author(s) -
Ueki Hisanori,
Ellis Trevor K.,
Martin Collin H.,
Soloshonok Vadim A.
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200200688
Subject(s) - chemistry , benzophenone , picolinic acid , ethyl chloroformate , glycine , amino acid , stereochemistry , organic chemistry , biochemistry
An efficient, large‐scale method for the preparation of 2‐[ N ‐(α‐picolyl)amino]acetophenone (PAAP) and 2‐[ N ‐(α‐picolyl)amino]benzophenone (PABP), the hitherto unknown 4‐methyl‐2‐[ N ‐(α‐picolyl)amino]benzophenone (4‐Me‐PABP) and 4‐nitro‐2‐[ N ‐(α‐picolyl)amino]benzophenone (4‐NO 2 ‐PABP), and their corresponding Ni II complexes with glycine is described. The key step of the method is the formation of the mixed anhydrides derived from o ‐picolinic acid and ethyl chloroformate or p ‐toluenesulfonyl chloride. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)