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Solvent‐Free Microwave‐Assisted Efficient Synthesis of 4,4‐Disubstituted 2‐Oxazolines
Author(s) -
GarcíaTellado Fernando,
Loupy André,
Petit Alain,
MarreroTerrero Alma Leilani
Publication year - 2003
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200200469
Subject(s) - chemistry , environmentally friendly , condensation , organic chemistry , zinc , solvent , lewis acids and bases , green chemistry , microwave , combinatorial chemistry , catalysis , reaction mechanism , ecology , biology , thermodynamics , physics , quantum mechanics
4,4‐Disubstituted 2‐oxazolines have been synthesized by a microwave‐promoted solvent‐free direct condensation of carboxylic acids and disubstituted β‐amino alcohols in good to excellent yields. Zinc oxide is a very good solid support in cases where a Lewis acid is required. The method described herein is a very good, safe, clean, economical, and environmentally friendly alternative to the classical procedures. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)