Premium
Back Cover: Eur. J. Lipid Sci. Technol. 10∕2017
Publication year - 2017
Publication title -
european journal of lipid science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 94
eISSN - 1438-9312
pISSN - 1438-7697
DOI - 10.1002/ejlt.201770104
Subject(s) - fatty acid synthase , monoacylglycerol lipase , fatty acid synthesis , lipid metabolism , acetyl coa carboxylase , atp citrate lyase , fatty acid , biochemistry , triple negative breast cancer , chemistry , enzyme , cancer , cancer research , pyruvate carboxylase , biology , breast cancer , endocannabinoid system , genetics , citrate synthase , receptor
Fatty acid metabolism and prospects for targeted therapy of cancer Tingting Chen and Hua Li DOI: 10.1002/ejlt.201600366 The levels of fatty acid (FA) de novo synthesis and degradation are elevated in cancer cells. Therefore, targeted inhibition of the key enzymes involved in FA metabolism, such as ATP‐citrate lyase (ACLY), acetyl‐CoA carboxylase (ACC), fatty acid synthase (FASN), monoacylglycerol lipase (MAGL), and stearoyl‐CoA desaturase 1 (SCD1), or utilization of anticancer exogenous FAs might be an effective way for cancer therapy.