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Two sides of the same coin: NEO‐PUFAs in Rett syndrome and post‐infarction cardiac arrhythmias
Author(s) -
Demion Marie,
Oger Camille,
Vigor Claire,
Thireau Jérôme,
Guennec JeanYves Le,
Durand Thierry,
Galano JeanMarie,
Lee Jetty ChungYung
Publication year - 2017
Publication title -
european journal of lipid science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 94
eISSN - 1438-9312
pISSN - 1438-7697
DOI - 10.1002/ejlt.201600320
Subject(s) - polyunsaturated fatty acid , oxidative stress , rett syndrome , antioxidant , chemistry , biochemistry , medicine , fatty acid , pharmacology , gene
An imbalance between oxidants and antioxidants that favors the oxidants leads to a disruption of the redox signaling control and/or molecular damage. The action of the oxidants in a non‐enzymatic process generates isoprostanoids from polyunsaturated fatty acids. In this review, we will focus on the effects of ω3‐polyunsaturated fatty acids in two different pathogeneses related to chronic and acute oxidative stress, one in neurodevelopmental, also known as the Rett syndrome, and the second in myocardial infarction and cardiac arrhythmias, respectively. We hypothesize that ω3‐polyunsaturated fatty acid supplementation displays antioxidant properties under a high oxidative stress situation, as in the Rett Syndrome, as well as protective properties of isoprostanoids from polyunsaturated fatty acids in pro‐arrhythmic conditions.