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A linker approach to phospholipopeptides
Author(s) -
Li Bonan,
Liang Jun F.
Publication year - 2016
Publication title -
european journal of lipid science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 94
eISSN - 1438-9312
pISSN - 1438-7697
DOI - 10.1002/ejlt.201400593
Subject(s) - phosphatidylethanolamine , linker , peptide , cysteine , chemistry , biochemistry , macromolecule , combinatorial chemistry , peptide synthesis , yield (engineering) , computational biology , biology , phospholipid , enzyme , computer science , materials science , phosphatidylcholine , membrane , metallurgy , operating system
Peptides and phospholipids are important macromolecules in both the chemistry and biology fields, but phospholipopeptides are barely found in nature and have not been studied. Here, we report a novel and efficient approach to the synthesis of phospholipidpeptides. By utilizing cross‐linkers, phospholipopeptides from peptides with varied sequences and lengths were produced from phosphatidylethanolamine at high (>90%) yield, mild conditions and good applied scopes for multiple substrates. Synthetic phospholipopeptides containing bioactive peptide sequences may serve as therapeutics for a wide range of biomedical applications. Practical applications: Phospholipopeptides are prone to hydrolysis by the endogenous phospholipase activity in cells. Synthetic phospholipopeptides containing a bioactive peptide sequences may serve as therapeutics for a wide range of biomedical applications. Cysteine‐containing peptides of varied sequences and lengths were linked to the heads of phosphatidylethanolamine through the amino group to form phospholipopeptides.