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Effect of Lactobacillus plantarum P‐8 on lipid metabolism in hyperlipidemic rat model
Author(s) -
Bao Yan,
Wang Zhanli,
Zhang Yong,
Zhang Jiachao,
Wang Lifeng,
Dong Ximei,
Su Fang,
Yao Guoqiang,
Wang Shuiquan,
Zhang Heping
Publication year - 2012
Publication title -
european journal of lipid science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 94
eISSN - 1438-9312
pISSN - 1438-7697
DOI - 10.1002/ejlt.201100393
Subject(s) - lactobacillus plantarum , hyperlipidemia , lipid metabolism , triglyceride , oxidative stress , cholesterol , probiotic , medicine , endocrinology , excretion , blood lipids , biology , chemistry , biochemistry , lactic acid , bacteria , diabetes mellitus , genetics
Probiotics have been reported to play an important role in the prevention of metabolic disorders. We recently identified a novel probiotic strain Lactobacillus plantarum ( L. plantarum ) P‐8. The objective of this study was to determine the effects of L. plantarum P‐8 on lipid metabolism of rats fed with high fat diet. All experimental rats were divided into three groups: control group, model group, and L. plantarum P‐8 group. Changes in serum lipid levels, hepatic lipid deposition, serum oxidative stress‐related parameters, activities of liver function marker enzymes, organ indices, gut microflora, and fecal lipids were assessed. Compared with model group, L. plantarum P‐8 exhibited hypolipidemic effects by lowering serum total cholesterol (TC), triglyceride (TG), and low‐density lipoprotein cholesterol levels, accompanied with elevation of high‐density lipoprotein cholesterol level. L. plantarum P‐8 also exerted beneficial effects against high‐fat diet‐induced oxidative stress, curtailed the accumulation of liver lipids and protected healthy liver function. Moreover, L. plantarum P‐8 was able to regulate intestinal bacteria and enhance the fecal excretion of TC, TG, and bile acid. These findings indicate that L. plantarum P‐8 may represent a potential therapeutic agent for controlling hyperlipidemia.