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Synergistic action between Caryocar coriaceum Wittm. fixed oil with aminoglycosides in vitro
Author(s) -
Saraiva Rogério A.,
Matias Edinardo F. F.,
Coutinho Henrique D. M.,
Costa José G. M.,
Souza Heloísa Helena F.,
Fernandes Cícera Norma,
Rocha João B. T.,
Menezes Irwin R. A.
Publication year - 2011
Publication title -
european journal of lipid science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 94
eISSN - 1438-9312
pISSN - 1438-7697
DOI - 10.1002/ejlt.201000555
Subject(s) - antimicrobial , antibiotics , minimum inhibitory concentration , microbiology and biotechnology , antibiotic resistance , nutraceutical , chemistry , staphylococcus aureus , biology , bacteria , food science , genetics
The oil obtained from the Caryocar coriaceum Wittm. ( pequi ) fruit pulp ( C. coriaceum fixed oil – CCFO), rich in fatty acids, has been secularly employed by traditional medicine in the treatment of respiratory affections, skin inflammation, and wounds. These observations encouraged us to investigate the antimicrobial activity of CCFO and to investigate its effect in combination with aminoglycosides. The minimum inhibitory concentration (MIC) of CCFO alone and associated with aminoglycosides against Escherichia coli and Staphylococcus aureus strains were determined using microdilution assay. CCFO alone had a MIC of 512 µg/mL against E. coli and S. aureus resistant strains. Combining the CCFO with aminoglycosides reduced the MIC of aminoglycosides against the resistant strains of E. coli and S. aureus . The results obtained indicate that CCFO displays a significant synergistic antibiotic effect when combined with aminoglycosides, demonstrating that the oil constituents (fatty acids) may act as potentiators of the antibiotic activity of aminoglycosides. These properties make CCFO oil an interesting alternative as a remedy or nutraceutical against multiresistant bacteria, preventing the development of resistance by these microorganisms. Practical applications: This article demonstrates the capacity of the C. coriaceum oil to enhance the antibiotic activity of aminoglycosides. This activity could represent a new way to combat the growing bacterial resistance to antibiotics, an important problem of public health.