Premium
Metabolism of trans and conjugated fatty acids
Author(s) -
Chardigny JeanMichel,
Clouet Pierre,
Combe Nicole,
QuignardBoulangé Annie,
Schmitt Bernard,
Lagarde Michel,
Léger ClaudeLouis
Publication year - 2007
Publication title -
european journal of lipid science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 94
eISSN - 1438-9312
pISSN - 1438-7697
DOI - 10.1002/ejlt.200600279
Subject(s) - conjugated linoleic acid , polyunsaturated fatty acid , bioconversion , chemistry , metabolic pathway , vaccenic acid , biochemistry , metabolism , conjugated system , fatty acid , linoleic acid , stereochemistry , organic chemistry , fermentation , polymer
Trans fatty acids (FA) enter all the metabolic pathways of bioconversion, oxidation and lipid storage and are incorporated into all tissues. They also interfere with the polyunsaturated FA metabolic pathways. Among trans FA, major attention is paid to elaidic and vaccenic acids. The latter is bioconverted into rumenic acid, a conjugated linoleic acid (CLA) isomer, through the Δ9 desaturase pathway. Considering CLA isomers, they are also bioconverted by desaturases and the elongation pathway, but the significance of this conversion is not fully understood. This review considers these different aspects, with particular attention to human data.