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Antioxidant properties of extracts and compounds from Psoralea morisiana
Author(s) -
Rosa Antonella,
Deiana Monica,
Corona Giulia,
Atzeri Angela,
Incani Alessandra,
Appendino Giovanni,
Dessì M. Assunta
Publication year - 2005
Publication title -
european journal of lipid science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 94
eISSN - 1438-9312
pISSN - 1438-7697
DOI - 10.1002/ejlt.200501183
Subject(s) - antioxidant , autoxidation , chemistry , petroleum ether , cytotoxicity , solvent , linoleic acid , vero cell , organic chemistry , biochemistry , traditional medicine , in vitro , fatty acid , extraction (chemistry) , medicine
The antioxidant activity of various extracts (MeOH, petroleum ether, EtOAc) from the aerial parts of Psoralea morisiana , an endemic Sardinian plant, was evaluated during autoxidation and iron‐mediated oxidation of linoleic acid at 37 °C and during cholesterol oxidation at 140 °C, in the absence of solvent. The activity of erybraedin C, bitucarpin A and plicatin B, isolated from the extracts, was investigated under the same experimental conditions and compared to that of BHT and α‐tocopherol. All the extracts, erybraedin C (major constituent of the extracts) and plicatin B showed powerful antioxidant properties. None of the extracts and pure compounds showed any prooxidant activity. The cytotoxicity of the extracts, erybraedin C, and plicatin B was further evaluated in VERO cells, a line of fibroblasts derived from monkey kidney. Erybraedin C, at non‐cytotoxic concentrations, showed a strong inhibition of FeCl 3 ‐induced oxidation in VERO cells.
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