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Feeding rats with liposomes or fish oil differently affects their lipid metabolism
Author(s) -
Cansell Maud,
Moussaoui Noredine,
Petit Alain Pierre,
Denizot Alain,
Combe Nicole
Publication year - 2006
Publication title -
european journal of lipid science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 94
eISSN - 1438-9312
pISSN - 1438-7697
DOI - 10.1002/ejlt.200500337
Subject(s) - fish oil , polyunsaturated fatty acid , liposome , bioavailability , food science , cholesterol , chemistry , lipid metabolism , corn oil , fatty acid , biochemistry , fish <actinopterygii> , biology , fishery , pharmacology
Two n‐ 3 polyunsaturated fatty acid (PUFA)‐rich diets differing in their chemical and physical forms were given to rats during 2 wk. Liposomes [phospholipids (PL) organized in bilayer structures] made from a natural marine lipid extract or a mixture of fats containing fish oil [similar fatty acids esterified in triacylglycerols (TAG)] were used. The influence of n‐ 3 PUFA dietary sources on plasma parameters, i.e. TAG, cholesterol and PL concentrations, was investigated. A similar hypotriglyceridemic effect of n‐ 3 PUFA from liposomes or fish oil was observed. In contrast, feeding rats with liposomes led to different PL and cholesterol patterns. In the plasma of rats fed liposomes, total cholesterol amounts were positively correlated with PL levels. Liposome and fish oil feedings caused a marked increase in the amounts of n‐ 3 PUFA, which occurred mainly at the expense of n‐ 6 PUFA. However, the enrichment in n‐ 3 PUFA in the different plasma lipid classes differed substantially when ingested in the form of fish oil or liposomes. These results were interpreted in terms of different lipid bioavailability and metabolic fate during the digestive steps and in the liver, with the dietary source.