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Effect of the MTP –493 G/T polymorphism on the lipid profiles of the Guangxi Hei Yi Zhuang and Han populations
Author(s) -
Ruixing Yin,
Rongshan Li,
Weixiong Lin,
Dezhai Yang,
Shangling Pan
Publication year - 2006
Publication title -
european journal of lipid science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 94
eISSN - 1438-9312
pISSN - 1438-7697
DOI - 10.1002/ejlt.200500281
Subject(s) - genotype , microsomal triglyceride transfer protein , allele , apolipoprotein b , traditional medicine , biology , population , hyperlipidemia , han chinese , polymorphism (computer science) , triglyceride , genetics , gene , cholesterol , lipoprotein , demography , medicine , single nucleotide polymorphism , very low density lipoprotein , endocrinology , diabetes mellitus , sociology
Abstract There are 56 nationalities in China. Han is the largest and Zhuang the second largest. Geographically and linguistically, Zhuang can be classified into 43 ethnic subgroups, in which Hei Yi (meaning black‐worship and black‐dressing) Zhuang is proved to be the most conservative group according to its unique culture and custom. Information on the genetic influence on the lipid profile is limited in this population. To obtain some of this information, a cross‐sectional survey of hyperlipidemia was carried out in 500 people of Hei Yi Zhuang and 500 people of Han in the same area. The genotypes and alleles of the microsomal triacylglycerol transfer protein (MTP –493 G/T) were also determined, by polymerase chain reaction combined with an allele‐specific oligonucleotide hybridization method, and then confirmed by direct sequencing. The frequencies of the G and T alleles were 0.74 and 0.26, respectively, in Hei Yi Zhuang, and 0.73 and 0.27 ( p >0.05) in Han. The frequencies of the GG, GT and TT genotypes were 0.58, 0.33 and 0.09, respectively, in Hei Yi Zhuang, and 0.56, 0.34 and 0.09 ( p >0.05) in Han. In the combined population of both Hei Yi Zhuang and Han, the levels of total cholesterol, triacylglycerol, low‐density lipoprotein cholesterol, and apolipoprotein B in the TT genotype were significantly higher than those in the GT ( p <0.05 to <0.01) or GG genotypes ( p <0.05 to <0.01), but there were no significant differences in their values between the GG and GT genotypes ( p >0.05). The levels of high‐density lipoprotein cholesterol and apolipoprotein A1 were not significantly different among the three genotypes ( p >0.05).